Arena E, D'Alessandro N, Dusonchet L, Geraci M, Rausa L, Sanguedolce R
Arzneimittelforschung. 1979;29(6):901-2.
Experiments in mice treated with a single 10 mg/kg dose of doxorubicin (adriamycin) i.p. revealed considerable reduction in the incorporation of 3H-thymidine in DNA and of 3H-uridine in RNA, in the spleen and liver, and at mitochondrial and non-mitochondrial level in the heart. Although protein syntheses in the heart and spleen were not reduced by the drug to any great degree, they took 10 days to return to normal; conversely, liver protein syntheses were not inhibited at all and indeed presented signs of stimulation.
对腹腔注射单剂量10mg/kg阿霉素（ Adriamycin）的小鼠进行的实验表明，在脾脏和肝脏以及心脏的线粒体和非线粒体水平上，DNA中3H-胸腺嘧啶核苷和RNA中3H-尿苷的掺入量显著减少。尽管该药物对心脏和脾脏中的蛋白质合成没有太大程度的降低，但它们需要10天才能恢复正常；相反，肝脏蛋白质合成完全没有受到抑制，实际上还呈现出刺激的迹象。
