Engler H, Lennartz H G, Schunack W
Arzneimittelforschung. 1979;29(6):911-2.
In particular, the action of N alpha-methyl-histamine has to be considered since its secretory response is approximately 1.5 times greater than that of histamine and its secretion lasted for a longer period of time. After C-5-alkylsubstitution, both 5-methyl-histamine and N alpha,5-dimethyl-histamine showed secretory action comparable to that of histamine; the agonistic activity, however, decreased with increasing chain length.
特别要考虑Nα-甲基组胺的作用，因为其分泌反应比组胺大约强1.5倍，且其分泌持续时间更长。在进行C-5-烷基取代后，5-甲基组胺和Nα,5-二甲基组胺均表现出与组胺相当的分泌作用；然而，激动活性随链长增加而降低。
