一种新型组胺H2受体特异性激动剂的生物学活性
Biological activities of a new specific stimulant of histamine H2 receptors.
作者信息
Bertaccini G, Impicciatore M, Vitali T
出版信息
Farmaco Sci. 1976 Dec;31(12):935-8.
PMID:1017487
Abstract
Compound N-methyl-2-(5-methyl-4-imidazolyl)ethylamine (5-methyl-N-methylhistamine) was submitted to a thorough pharmacological examination and was found to be a potent stimulant of H2 receptors, devoid of any appreciable effect on H1 receptors. Because of its high degree of specificity it therefore seems to represent an interesting drug to be used in clinical gastric secretory tests and an useful tool for the study of histamine H2 receptors.
摘要
化合物N-甲基-2-(5-甲基-4-咪唑基)乙胺（5-甲基-N-甲基组胺）经过了全面的药理学检查，结果发现它是一种强效的H2受体激动剂，对H1受体没有任何明显作用。由于其高度的特异性，它似乎是一种可用于临床胃分泌试验的有趣药物，也是研究组胺H2受体的有用工具。
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Biological activities of a new specific stimulant of histamine H2 receptors.一种新型组胺H2受体特异性激动剂的生物学活性
Farmaco Sci. 1976 Dec;31(12):935-8.
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[N-Alkyl-2-(5-methyl-4-imidazolyl)ethylamines. Synthesis and effect on gastric secretion].[N-烷基-2-(5-甲基-4-咪唑基)乙胺。合成及其对胃酸分泌的影响]
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