Hempelmann F W, Heinz N
Arzneimittelforschung. 1978;28(12):2185-7.
By equilibrium dialysis the binding of 19 cardenolides and cardenolide conjugates to human plasma proteins has been measured. The binding constants were compared with octanol-water partition coefficients described previously. No correlation was found between the two properties. Glycosides and conjugates of a certain genine show the same extent of protein binding, even if some of the derivatives differ in their physicochemical properties more than by three log units. It is concluded that cardenolide protein binding depends solely on hydrophobic property of the genine involved.
通过平衡透析法测定了19种强心苷及其结合物与人血浆蛋白的结合情况。将结合常数与先前描述的正辛醇 - 水分配系数进行了比较。未发现这两种性质之间存在相关性。即使某些衍生物的理化性质差异超过三个对数单位，特定苷元的糖苷和结合物仍表现出相同程度的蛋白质结合。得出的结论是，强心苷与蛋白质的结合仅取决于所涉及苷元的疏水性质。
