Berg B N, Simms H S
Can Med Assoc J. 1965 Oct 23;93(17):911-3.
The effect of food restriction in rats to a level 46% below the intake of those fed ad libitum was studied in relation to onset of disease and longevity. Dietary restriction at this level kept adult rats in a nutritional state short of the development of excess body fat, and had little effect on skeletal growth or sexual maturity. Onset of microscopically observed renal, vascular, myocardial and skeletal muscle lesions, as well as mammary fibroadenoma in females, was delayed and resulted in greater longevity. Life expectancy of male rats was increased by 25% and of females by 39%. Time of onset of disease appears to be regulated by a common factor which is influenced by dietary intake.
研究了将大鼠食物摄入量限制在自由采食大鼠摄入量以下46%的水平对疾病发生和寿命的影响。这种水平的饮食限制使成年大鼠处于缺乏过多体脂形成的营养状态，对骨骼生长或性成熟影响很小。显微镜下观察到的肾脏、血管、心肌和骨骼肌病变以及雌性大鼠乳腺纤维腺瘤的发病延迟，并导致更长的寿命。雄性大鼠的预期寿命增加了25%，雌性大鼠增加了39%。疾病的发病时间似乎受一个受饮食摄入量影响的共同因素调节。
