Bramanti G, Murmann W, Pierini P, Comporti M
Arzneimittelforschung. 1978;28(7a):1212-7.
The effects of cis-2-hydroxy-2-phenyl-cyclohexanecarboxilic acid (cicloxilic acid) on the liver injury produced by carbon tetrachloride poisoning were studied in rats. It was found that oral treatment counteracts the CCl4-induced increase in liver weight, rise of liver triglycerides, fall of plasma triglycerides and rise of serum transaminase and ornithine carbamoyl transferase activities. Further, cicloxilic acid, when administered alone, altered none of the parameters studied. Cicloxilic acid was found to be more effective at the lowest doses than any of the other antihepatotoxic and choleretic drugs used. When cicloxilic acid was administered at the highest doses, the plasma triglyceride level of the intoxicated animals was not significantly different from that of the controls. To find out whether cicloxilic acid was effective in maintaining a normal lipoprotein secretion after CCl4 poisoning, experiments were carried out with Triton WR-1339. The results indicate that cicloxilic acid maintains the output of triglycerides from the liver to the plasma compartment at near-normal level in CCl4 poisoned rats. Possible mechanisms for the effects of cicloxilic acid on the CCl4-induced liver damage are discussed.
在大鼠中研究了顺式 - 2 - 羟基 - 2 - 苯基 - 环己烷羧酸（环氯噻嗪酸）对四氯化碳中毒所致肝损伤的影响。发现口服治疗可抵消四氯化碳诱导的肝脏重量增加、肝脏甘油三酯升高、血浆甘油三酯降低以及血清转氨酶和鸟氨酸氨甲酰转移酶活性升高。此外，单独给予环氯噻嗪酸时，所研究的参数均未改变。发现环氯噻嗪酸在最低剂量时比所使用的任何其他抗肝毒性和利胆药物都更有效。当以最高剂量给予环氯噻嗪酸时，中毒动物的血浆甘油三酯水平与对照组无显著差异。为了弄清楚环氯噻嗪酸在四氯化碳中毒后维持正常脂蛋白分泌方面是否有效，用曲拉通WR - 1339进行了实验。结果表明，环氯噻嗪酸在四氯化碳中毒的大鼠中可将肝脏甘油三酯向血浆部分的输出维持在接近正常的水平。讨论了环氯噻嗪酸对四氯化碳诱导的肝损伤产生作用的可能机制。
