Bramanti G, Murmann W, Pierini P, Comporti M
Arzneimittelforschung. 1978;28(7a):1207-11.
The effects of cis-2-hydroxy-2-phenylcyclohexanecarboxilic acid (cicloxilic acid) on the liver damage produced by a choline-free, high-fat low-protein diet (Handler's diet) were studied in rats. Treatment with cicloxilic acid significantly counteracted the increase in liver weight, hepatic lipids, serum transaminase and ornithine carbamoyl transferase activities, caused by the unbalanced and deficient diet. Histological examination of the liver showed a near-normal structure of the hepatic cells in the cicloxilic acid-treated animals. Other antihepatotoxic and choleretic drugs, with which cicloxilic acid was compared, showed either much less protective activity or none at all. Furthermore, while cicloxilic acid (which exhibits choleretic activity) did not alter the hepatic glycogen content, another choleretic drug, 1-phenyl-1-hydroxypentane (PC 1), caused marked depletion. It is concluded that the protective activity exerted by cicloxilic acid on the liver is separable from its choleretic activity.
在大鼠中研究了顺式-2-羟基-2-苯基环己烷羧酸（环氯噻嗪酸）对无胆碱、高脂肪低蛋白饮食（汉德勒饮食）所致肝损伤的影响。环氯噻嗪酸治疗显著对抗了由不均衡和缺乏饮食引起的肝脏重量增加、肝脂质、血清转氨酶和鸟氨酸氨基甲酰转移酶活性升高。肝脏组织学检查显示，用环氯噻嗪酸治疗的动物肝细胞结构接近正常。与环氯噻嗪酸比较的其他抗肝毒性和利胆药物，要么保护活性低得多，要么根本没有保护活性。此外，虽然环氯噻嗪酸（具有利胆活性）没有改变肝糖原含量，但另一种利胆药物1-苯基-1-羟基戊烷（PC 1）却导致明显消耗。得出的结论是，环氯噻嗪酸对肝脏的保护活性与其利胆活性是可分离的。
