Zuin M, Di Padova C, Rovagnati P, Lasala G, Cammareri G
Arzneimittelforschung. 1979;29(5):837-8.
Cholesterol supersaturation of gallbladder bile induced by oral contraceptives is significantly reduced by the administration of cis-2-hydroxy-2-phenyl-cyclohexane-carboxilic acid (cicloxilic acid), a choleretic substance which has been demonstrated to exert an antilithogenic effect in the rat and in man.
口服避孕药所致的胆囊胆汁胆固醇过饱和状态,通过给予顺式-2-羟基-2-苯基环己烷羧酸(环氯噻嗪酸)可得到显著降低,环氯噻嗪酸是一种利胆物质,已证实其在大鼠和人类中均具有抗结石形成作用。