[Effect of cicloxilic acid on biliary dynamics].

This work was developed in order to estimate, with objective methods, the pharmacodynamic activities of a new choleretic and antilithogenic drug, the cicloxilic acid. It was determined the changes of daily biliary flow and bile composition in 8 patients with biliary system surgical intervention and "T" (Kehr) tube inserted. The cicloxilic acid was given in the dose of 240 mg/day. The results showed, after treatment, an emphasized middle volume increase of the excreted bile, as well as a significant decrease of the biliary cholesterol, while pH and density maintained constants. The results corroborated the pharmacodynamic activities given to cicloxilic acid as a "true" choleretic to be utilized in clinic situations where it's wished a biliary flow increase and the possibility to avoid a cholesterol lithiasis or relieve consequent disturbances.