Hladovec J
Arzneimittelforschung. 1979;29(8):1101-3.
Calcium antagonists possess, similarly to endothelotropic (vasotropic) drugs, a stabilizing effect on endothelium against the disrupting influence of citrate in rats. This was demonstrated with the new method for counting of circulating endothelial cells. The effect is dose related and the effective experimental dosages corresponded closely to the clinical dose range. The common link between both drug groups is probably the mediating effect of ionic calcium.
钙拮抗剂与作用于内皮(血管)的药物类似,对大鼠内皮具有稳定作用,可抵抗柠檬酸盐的破坏作用。这是通过循环内皮细胞计数的新方法得以证明的。该作用与剂量相关,有效实验剂量与临床剂量范围密切对应。这两类药物之间的共同联系可能是离子钙的介导作用。