Banerjee B N, Sofia R D, Ivins N J, Ludwig B J
Arzneimittelforschung. 1979;29(8):1141-5.
The acute and subacute toxicity of 4-(p-chlorophenylthio) butanol (W-2719), on anti-allergy agent, was investigated in mice, rats and dogs. Acute LD50 values in the mouse (1145.0 mg/kg p.o.) and rat (greater than 1400.0 mg/kg p.o.) and maximum tolerated dose in the dog (420.0 mg/kg p.o.) were very high, indicative of a high degree of safety following a single oral dose. The subacute toxicity studies were conducted by repeated daily oral administration of the compound for 30 days. In the rat, W-2719 did not produce any significant toxicity up to a dose level of 100.0 mg/kg/day, when administered as a drug-diet admixture. A higher dose, i.e., 200.0 mg/kg/day, produced marked reductions in body weight gain, food consumption, RBC and WBC (females especially), and other hematological parameters. In the purebred beagle dog, W-2719 did not produce any significant toxicity up to a dose level of 100.0 mg/kg/day, the highest dose level tested in this species.
对一种抗过敏剂4-(对氯苯硫基)丁醇（W-2719）进行了小鼠、大鼠和犬的急性及亚急性毒性研究。小鼠的急性半数致死量（经口给药为1145.0毫克/千克）、大鼠的急性半数致死量（经口给药大于1400.0毫克/千克）以及犬的最大耐受剂量（经口给药为420.0毫克/千克）都非常高，表明单次口服给药后安全性很高。亚急性毒性研究通过连续30天每日经口重复给予该化合物进行。在大鼠中，当以药物-饲料混合物形式给药时，W-2719在剂量水平达100.0毫克/千克/天时未产生任何显著毒性。更高剂量，即200.0毫克/千克/天，导致体重增加、食物消耗、红细胞和白细胞（尤其是雌性大鼠）以及其他血液学参数显著降低。在纯种比格犬中，W-2719在剂量水平达100.0毫克/千克/天时未产生任何显著毒性，这是该物种所测试的最高剂量水平。
