Banerjee B N, Sofia R D, Ivins N J, Ludwig B J
Arzneimittelforschung. 1977;27(4):793-801.
The acute and subactue toxicity of 2,3-dihydro-9H-isoxazolo[3,2-b]quinazolin-9-one (W-2429), a non-narcotic analgesic agent, was investigated in mice, rats and dogs. The subacute toxicity study was conducted by repeated oral administration of the compound for 30 days. Treatment with W-2429 was well tolerated by rats as well as dogs. In the dog, the only signs of toxicity observed were decreased appetite and salivation at 100 mg/kg/day. No other significant evidence of physical, chemical, gross or histopathologic change was observed.
对非麻醉性镇痛药2,3 - 二氢 - 9H - 异恶唑并[3,2 - b]喹唑啉 - 9 - 酮（W - 2429）进行了小鼠、大鼠和犬的急性及亚急性毒性研究。亚急性毒性研究通过对该化合物进行30天的重复口服给药来进行。大鼠和犬对W - 2429治疗的耐受性良好。在犬中，观察到的唯一毒性迹象是在剂量为100 mg/kg/天时出现食欲减退和流涎。未观察到其他明显的生理、化学、大体或组织病理学变化的证据。
