Haegerstam G, Evers H, Broberg F
Arzneimittelforschung. 1979;29(8):1177-9.
By means of experiments involving pin-pricking, compositions containing 10% ketocaine base in a mixture of 2-propanol, glycerol and water were found to produce a high frequency of block to cutaneous pain following application to volunteers under an occlusive dressing. The local analgesic efficacy was found to be directly related to the degree of saturation of ketocaine in the vehicle and time of application. The degree of hyperaemia observed in the treated skin areas was found to be related to the degree of local analgesia produced.
通过涉及针刺的实验发现，在2-丙醇、甘油和水的混合物中含有10%酮卡因碱的组合物，在封闭敷料下应用于志愿者后，会产生高频率的皮肤疼痛阻滞。发现局部镇痛效果与酮卡因在载体中的饱和程度和应用时间直接相关。发现在治疗皮肤区域观察到的充血程度与产生的局部镇痛程度有关。
