Nakamura M, Kano T, Hashiguchi A, Shimoda O, Kato K, Shimizu Y, Morioka T, Mishima M, Yasutake S, Nakano M
Department of Anesthesiology, Kumamoto University Hospital.
Masui. 1990 May;39(5):568-71.
The analgesic effects of aqueous gel containing 2% or 10% lidocaine with 3% glycyrrhetinic acid mono 3-0 hemiphthalate sodium as an absorption promoter were compared in two volunteer groups of 12 persons each. A round sponge (25 mm in diameter and 1mm in thickness) filled with approximately 0.3g of either gel was applied on the volar surface of the forearm and kept covered with an adhesive plastic film (Tegaderm) for two hours. The analgesic effect was assessed every 30 min by pin-prick method at five places under the coverage for two hours, and after the gel was wiped away. The result from each place was scored 0 (no pain) or 1 (needle pain). The mean pain scores at 1 hr and 1.5 hr in the 10% group were 1.0 and 0.7, and significantly lower than 2.2 and 1.3 of the 2% group (P less than 0.05). Two hour application of the gel, five volunteers in the 2% group and eight volunteers in the 10% group produced a pain score under 1.0. In these subjects, a 26 gauge needle was stuck into the skin for further pain analysis. Four of the 5 subjects in the 2% group and 7 of the 8 subjects in the 10% group did not complain of any pain. Transient local redness under the coverage was observed in 3 subjects in each group. They were all known to be sensitive to alcoholic beverages. No other side effects were found. The plasma concentration of lidocaine was lower than 0.01 microgram.ml-1 at all times.
在两个各有12名志愿者的小组中，比较了含有2%或10%利多卡因以及3%甘草次酸单3 - 0半酞酸钠作为吸收促进剂的水凝胶的镇痛效果。将一块填充有大约0.3g任一种凝胶的圆形海绵（直径25mm，厚度1mm）贴在前臂掌侧表面，并用粘性塑料薄膜（德莫肤）覆盖两小时。在覆盖区域下的五个部位，每隔30分钟通过针刺法评估两小时的镇痛效果，凝胶擦去后也进行评估。每个部位的结果记为0分（无疼痛）或1分（针刺疼痛）。10%组在1小时和1.5小时时的平均疼痛评分分别为1.0和0.7，显著低于2%组的2.2和1.3（P小于0.05）。凝胶涂抹两小时后，2%组有5名志愿者、10%组有8名志愿者的疼痛评分低于1.0。在这些受试者中，将一根26号针头刺入皮肤进行进一步的疼痛分析。2%组的5名受试者中有4名、10%组的8名受试者中有7名没有主诉任何疼痛。每组各有3名受试者在覆盖区域下观察到短暂的局部发红。已知他们都对酒精饮料敏感。未发现其他副作用。利多卡因的血浆浓度在所有时间均低于0.01微克·毫升⁻¹。
