Anttila M, Kahela P, Panelius M, Yrjänä T, Tikkanen R, Aaltonen R
Eur J Clin Pharmacol. 1979 Jul;15(6):421-5. doi: 10.1007/BF00561742.
A comparative bioavailability study was performed using two commercially available types of carbamazepine tablets, by statistical analysis of serum levels and other bioavailability parameters. After single oral dose the extent of absorption from the two preparations was similar, although a statistically significant difference in absorption rates was observed. In a multiple-dose study no significant difference in serum carbamazepine levels was found, so the tablets could be considered as bioequivalent drug products.
通过对血清水平和其他生物利用度参数进行统计分析，使用两种市售类型的卡马西平片进行了一项生物利用度对比研究。单次口服给药后，两种制剂的吸收程度相似，尽管在吸收速率上观察到有统计学显著差异。在多剂量研究中，未发现血清卡马西平水平有显著差异，因此这些片剂可被视为生物等效的药品。
