Chesney J C, Gourley G R, Peters M E, Moffet H L
Am J Dis Child. 1979 Nov;133(11):1134-9. doi: 10.1001/archpedi.1979.02130110042005.
Two children, aged 3 months and 4 years, respectively, were treated with ten weeks of amphotericin B for culture proved pulmonary blastomycosis. Organisms were easily demonstrated in nasopharyngeal or sputum specimens on admission. Although organisms were present until the 12th and 19th days of therapy, respectively, they were viable through only the seventh and 12th days of therapy. Both patients had thrombophlebitis, anemia, neutropenia, hypokalemia, fever, and vomiting develop during therapy. The less toxic drug hydroxystilbamidine isethionate, given for only 17 to 30 days, has been used successfully in at least six previously reported cases. Long courses of amphotericin B therapy may not be necessary for the treatment of pulmonary blastomycosis in selected children.
两名分别为3个月和4岁的儿童因培养证实的肺芽生菌病接受了为期十周的两性霉素B治疗。入院时，在鼻咽或痰液标本中很容易发现病原体。尽管病原体分别在治疗的第12天和第19天仍存在，但它们仅在治疗的第7天和第12天具有活力。两名患者在治疗期间均出现了血栓性静脉炎、贫血、中性粒细胞减少、低钾血症、发热和呕吐。毒性较小的药物羟乙磺酸羟脒替，仅使用17至30天，在至少六例先前报道的病例中已成功使用。对于选定的儿童，治疗肺芽生菌病可能无需长期使用两性霉素B。
