Raasch E, Kietzer I
Arzneimittelforschung. 1979;29(10):1544-6.
Cephalosporins, especially cephaloridine (Kefspor), are examined in vitro for their influence on several methods for the determination of creatinine. Two chemical methods frequently used in clinical laboratories (Jaffé test reaction) and one enzymatic creatinine analysis are used for this purpose. Depending on the quality of cephalosporin added, excessively high creatinine contents are determined with the two chemical methods, whereas there seems to be no effect on the enzymatic creatinine determination method. The significance of these findings for clinical diagnostics is discussed.
对头孢菌素，尤其是头孢噻啶（先锋霉素Ⅱ），进行了体外研究，以考察其对几种肌酐测定方法的影响。为此使用了临床实验室常用的两种化学方法（Jaffé试验反应）和一种酶法肌酐分析方法。根据添加头孢菌素的质量，用这两种化学方法会测定出过高的肌酐含量，而对酶法肌酐测定方法似乎没有影响。讨论了这些发现对临床诊断的意义。
