Kucharczyk N, Edelson J, Sofia R D, Ludwig B J, Shahinian S, Schuster E, Ballard F H, Yang J, Myers G
Arzneimittelforschung. 1979;29(10):1550-6.
4-(p-Chlorophenylthio)butanol (W-2719) administered orally to rats and dogs is rapidly absorbed, metabolized and excreted. The only major biotransformation product found in blood was p-chlorophenylthioacetic acid (W-2683). No W-2719 or the intermediary p-chlorophenylthiobutyric acid (W-2718) could be found in plasma after oral administration of the drug. When W-2719 was given i.v. to dogs, both W-2719 and W-2718 appeared in plasma but each had a very short half-life of about 10 min. After an oral dose of W-2719 to dogs the plasma content of W-2683 peaked at 4-6 h, amounting to approximately 20% of the dose. More than 91% of the dose was excreted with 48 h, 83% in urine and 9% in feces. The predominant excretion product in urine was p-chlorothiophenol, most of which was excreted in a conjugated form. The other major urinary metabolite was W-2683, while smaller amounts of W-2718 and unchanged drug were also found. No significant effect of prolonged dosing of 14C-W-2719 to dogs was observed on plasma 14C levels, peak time, 14C half-life or excretion and composition patterns.
4-（对氯苯硫基）丁醇（W-2719）经口服给予大鼠和狗后，会迅速被吸收、代谢和排泄。血液中发现的唯一主要生物转化产物是对氯苯硫基乙酸（W-2683）。口服该药物后，血浆中未发现W-2719或中间产物对氯苯硫基丁酸（W-2718）。当给狗静脉注射W-2719时，W-2719和W-2718均出现在血浆中，但它们的半衰期都很短，约为10分钟。给狗口服一剂W-2719后，W-2683的血浆含量在4至6小时达到峰值，约占剂量的20%。超过91%的剂量在48小时内排出，83%通过尿液排出，9%通过粪便排出。尿液中主要的排泄产物是对氯苯硫酚，其中大部分以结合形式排出。另一种主要的尿液代谢产物是W-2683，同时也发现了少量的W-2718和未变化的药物。对狗长期给予14C-W-2719，未观察到对血浆14C水平、峰值时间、14C半衰期或排泄及组成模式有显著影响。
