Meeks R G, Bayer B M, Sofia R D, Bianchine J R, Couri D
Arzneimittelforschung. 1979;29(11):1756-8.
4-(p-Chlorophenylthio)butanol (W-2719) is absorbed, metabolized and excreted when administered orally to human volunteers. The butyrate (W-2718) and the acetate (W-2683) metabolites were found in plasma with W-2683 being the major biotransformation product and detectable seven days after administration with an apparent half-life of 33.2 h. p-Chlorothiophenol appeared to be the major biotransformation product in urine and was detectable through day 6. As in plasma, the other major biotransformation product was W-2683, which was again detectable through day 7 and had a t 1/2 in urine of 40.8 h. The minor metabolite found in urine was W-2718. No W-2719 was found in either plasma or urine after oral administration.
4-（对氯苯硫基）丁醇（W-2719）口服给予人类志愿者后会被吸收、代谢和排泄。血浆中发现了丁酸酯（W-2718）和乙酸酯（W-2683）代谢物，其中W-2683是主要的生物转化产物，给药后7天仍可检测到，表观半衰期为33.2小时。对氯苯硫酚似乎是尿液中的主要生物转化产物，在第6天仍可检测到。与血浆中一样，另一种主要生物转化产物是W-2683，在第7天仍可检测到，在尿液中的t1/2为40.8小时。尿液中发现的次要代谢物是W-2718。口服给药后，血浆或尿液中均未发现W-2719。
