Ebel S, Schütz H
Arzneimittelforschung. 1979;29(9):1317-25.
The article describes analytical data (TLC, IR, MS) of 7-chloro-1-methyl-1,3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one (3-hydroxydiazepam) and 7-cyclopropyl-methyl-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazpin-2-one (3-hydroxy-prazepam). Analytical properties of important derivatives (N-oxides, 3-acetoxy compounds, re-arrangement products) are also reported. Besides preparation methods are given for the synthesis of these substances, considering in particular preparation as solution-reactions as well as reaction on the TLC-plate.
本文描述了7-氯-1-甲基-1,3-二羟基-5-苯基-2H-1,4-苯并二氮杂䓬-2-酮（3-羟基地西泮）和7-环丙基甲基-1,3-二氢-3-羟基-5-苯基-2H-1,4-苯并二氮杂䓬-2-酮（3-羟基普拉西泮）的分析数据（薄层色谱法、红外光谱法、质谱法）。还报道了重要衍生物（N-氧化物、3-乙酰氧基化合物、重排产物）的分析性质。此外，给出了这些物质的合成制备方法，特别考虑了作为溶液反应以及在薄层色谱板上的反应的制备方法。
