一系列新型苯二氮䓬类药物。1,3 - 二氢 - 2H - 1,4 - 苯二氮䓬 - 2 - 酮的1 - 羟烷基衍生物。
A new series of benzodiazepines. 1-Hydroxyalkyl derivatives of 1,3-dihydro-2H-1,4-benzodiazepin-2-ones.
作者信息
Tamagnone G F, De Maria R, De Marchi F
出版信息
Arzneimittelforschung. 1975 May;25(5):720-2. doi: 10.1002/chin.197534291.
PMID:1242312
Abstract
A series of new 1-hydroxyalkyl derivatives of 1,3-dihydro-2H-1,4-benzodiazepin-2-ones bearing a 3-hydroxyl or a 4-N-oxide function together with some related compounds have been synthesized. Compound (22) [1-(2-hydroxyethyl)-3-hydroxy-7-chloro-1,3-dihydro-5-(o-fluorophenyl)-2H-1,4-benzodiazepin-2-one] has been selected for further studies both in animals and in humans as an antianxiety-sedative agent.
摘要
一系列带有3-羟基或4-N-氧化物官能团的1,3-二氢-2H-1,4-苯并二氮杂卓-2-酮的新型1-羟烷基衍生物以及一些相关化合物已被合成。化合物（22）[1-(2-羟乙基)-3-羟基-7-氯-1,3-二氢-5-(邻氟苯基)-2H-1,4-苯并二氮杂卓-2-酮]已被选作抗焦虑镇静剂在动物和人体中进行进一步研究。
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