必需脂肪酸缺乏对发育中大鼠脑内[1(-14)C]亚麻酸代谢转化的影响。
The effect of essential fatty acid deprivation on the metabolic transformations of [1(-14)C]linolenate in developing rat brain.
作者信息
Dwyer B E, Bernsohn J
出版信息
Biochim Biophys Acta. 1979 Dec 18;575(3):309-17. doi: 10.1016/0005-2760(79)90099-7.
PMID:583255
Abstract
Linolenic acid undergoes rapid metabolism in the brain of 21-day-old rats. Radioactivity is rapidly transferred from linolenic acid to the C20 (n--3) fatty acids while that in docosapentaenoic acid (22 : 5 n--3) and docosahexaenoic acid (22 : 6 n--3) gradually increases. A greater proportion of the radioactivity is associated with the polyunsaturated and less with saturated and monounsaturated fatty acids in essential fatty acid-deprived rats relative to controls.
摘要
在21日龄大鼠的大脑中，亚麻酸经历快速代谢。放射性物质迅速从亚麻酸转移至C20（n-3）脂肪酸，而二十二碳五烯酸（22:5 n-3）和二十二碳六烯酸（22:6 n-3）中的放射性物质则逐渐增加。与对照组相比，在必需脂肪酸缺乏的大鼠中，更大比例的放射性物质与多不饱和脂肪酸相关，而与饱和脂肪酸和单不饱和脂肪酸相关的比例较小。
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