Hassam A G, Rivers J P, Crawford M A
J Nutr. 1977 Apr;107(4):519-24. doi: 10.1093/jn/107.4.519.
Female rats were weaned and fed a semipurified diet lacking in essential fatty acids. After 160 days, the deficient diet was supplemented with varying amounts of gamma-linolenic acid. Changes in body weight and feed efficiency were measured. Total liver phospholipid fatty acids were also analyzed. Supplementation with gamma-linolenic acid to the deficient diet for 7 days led to improvements in body weight and feed efficiency of the deficient rats. The liver phospholipid fatty acid composition returned to a normal pattern. There was a reduction of 5,8,11-eicosatrienoic acid and an increase in the arachidonic acid. Thus, there was a fall in the triene: tetraene ratio with increasing dietary supplementation of gamma-linolenic acid. The essential fatty acid potency, the minimum dietary requirement for this fatty acid, and the widely accepted levels of the minimum requirements of dietary essential fatty acids are discussed.
将雌性大鼠断奶后，给它们喂食缺乏必需脂肪酸的半纯化饮食。160天后，在缺乏脂肪酸的饮食中添加不同量的γ-亚麻酸。测量体重和饲料效率的变化。同时也分析了肝脏总磷脂脂肪酸。给缺乏脂肪酸的大鼠在其缺乏饮食中补充γ-亚麻酸7天，可使体重和饲料效率得到改善。肝脏磷脂脂肪酸组成恢复到正常模式。5,8,11-二十碳三烯酸减少，花生四烯酸增加。因此，随着饮食中γ-亚麻酸补充量的增加，三烯:四烯比值下降。文中讨论了必需脂肪酸效力、该脂肪酸的最低饮食需求量以及广泛接受的饮食必需脂肪酸最低需求量水平。
