Solomons N W, García-Ibáñez R, Aycinena P, Torún B, Viteri F E
Arq Gastroenterol. 1979 Jul-Sep;16(3):137-45.
A non-invasive, interval sampling hydrogen (H2) breath-analysis test for carbohydrate malabsorption was used in a 3 year-old Guatemalan child with severe protein-energy malnutrition (kwashiorkor) and in this relatives: mother half-sister and step-father to examine genetic and nutritional factors in lactose intolerance in young children. Clinical lactose intolerance was present in the patient on admission, and lactose malabsorption, even of 0.88 g per kg of weight, persisted after complete nutritional recobly due to gastric retention of the substrate. Malabsorption of a physiological dose of lactose, 12.5 g, was detected in the mother and step-father while their daughter exhibited normal growth and development and normal lactose absorption at 8 months of age. The H2 breath test proved to be a sensitive, well-tolerated procedure for both adults and young children. Pitfalls, such as delayed gastric emptying, absence of normal bacterial flora, prior use of antibiotics, must be considered in interpreting H2 breath test results in children.
对一名患有严重蛋白质 - 能量营养不良（夸希奥科病）的3岁危地马拉儿童及其亲属（母亲、同父异母妹妹和继父）进行了一项用于检测碳水化合物吸收不良的非侵入性间歇采样氢气（H2）呼气分析测试，以研究幼儿乳糖不耐受的遗传和营养因素。入院时患者存在临床乳糖不耐受，由于底物的胃潴留，即使每公斤体重摄入0.88克乳糖，在完全营养恢复后乳糖吸收不良仍持续存在。母亲和继父检测到生理剂量12.5克乳糖吸收不良，而他们的女儿在8个月大时生长发育正常且乳糖吸收正常。H2呼气试验被证明是一种对成人和儿童都敏感且耐受性良好的检测方法。在解读儿童H2呼气试验结果时，必须考虑一些影响因素，如胃排空延迟、缺乏正常细菌菌群、先前使用过抗生素等。
