组织培养中细胞的被动免疫杀伤
Passive immune kill of cells in tissue culture.
作者信息
Hamburger R N, Mills S E
出版信息
Immunology. 1965 May;8(5):454-60.
Abstract
Mammalian cells in tissue culture can bind foreign protein to the cell surface and be killed by antiserum with specificity directed to the foreign antigen. The reaction is complement-dependent and, by analogy to passive immune haemolysis, is termed passive immune kill. Passive immune kill is specifically inhibited by incorporation of the foreign protein, in antigen excess, into the reaction mixture. The relevance of these observations to cell injury by immunologic mechanisms occurring is discussed.
摘要
组织培养中的哺乳动物细胞可将外源蛋白结合到细胞表面，并被针对该外源抗原的特异性抗血清杀死。该反应依赖补体，类似于被动免疫溶血，被称为被动免疫杀伤。通过在反应混合物中加入过量抗原形式的外源蛋白，可特异性抑制被动免疫杀伤。本文讨论了这些观察结果与免疫机制导致的细胞损伤的相关性。
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1
Nutrition of animal cells in tissue culture; initial studies on a synthetic medium.组织培养中动物细胞的营养；对合成培养基的初步研究。
Proc Soc Exp Biol Med. 1950 Jan;73(1):1-8. doi: 10.3181/00379727-73-17557.
2
CLONAL GROWTH OF PRIMARY HUMAN CELL CULTURES.原代人细胞培养的克隆生长
Exp Cell Res. 1964 Feb;33:495-507. doi: 10.1016/0014-4827(64)90014-x.
3
A MECHANISM OF CELL DESTRUCTION IN INDIVIDUALS SENSITIZED TO FOREIGN ANTIGENS AND ITS IMPLICATIONS IN AUTO-IMMUNITY. COMBINED CLINICAL STAFF CONFERENCE AT THE NATIONAL INSTITUTES OF HEALTH.对异种抗原敏感个体的细胞破坏机制及其在自身免疫中的意义。国立卫生研究院联合临床工作人员会议
Ann Intern Med. 1964 Mar;60:506-21. doi: 10.7326/0003-4819-60-3-506.
4
ANTIGENIC SPECIFICITIES ACQUIRED FROM THE GROWTH MEDIUM BY CELLS IN TISSUE CULTURE.组织培养中的细胞从生长培养基获得的抗原特异性。
Immunology. 1963 Sep;6(5):439-49.
5
Sensitization of infant red cells by bacterial polysaccharides of Escherichia coli during enteritis.肠炎期间大肠杆菌细菌多糖对婴儿红细胞的致敏作用。
J Pediatr. 1962 Feb;60:172-6. doi: 10.1016/s0022-3476(62)80032-8.
6
Clonal growth of mammalian cells in vitro; growth characteristics of colonies from single HeLa cells with and without a feeder layer.哺乳动物细胞的体外克隆生长；有无饲养层时单个海拉细胞形成的集落的生长特性。
J Exp Med. 1956 Feb 1;103(2):273-83. doi: 10.1084/jem.103.2.273.
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