磷脂膜与聚乙二醇的相互作用。
Interaction of phospholipid membranes with poly(ethylene glycol)s.
作者信息
Tilcock C P, Fisher D
出版信息
Biochim Biophys Acta. 1979 Oct 19;557(1):53-61. doi: 10.1016/0005-2736(79)90089-0.
PMID:583569
Abstract
- The water-soluble polymer, poly(ethylene glycol), causes concentration-dependent increases in the temperature of the gel--liquid crystalline phase transitions of aqueous dispersions of dipalmitoyl phosphatidylcholine and of dipalmitoyl phosphatidylethanolamine. 2. For dipalmitoyl phosphatidylcholine it has been further demonstrated that poly(ethylene glycol) increases the transition enthalpy and entropy while decreasing the cooperativity of the transition. 3. These results are discussed in relation to the possible modes of action of poly(ethylene glycol) in promoting cell fusion.
摘要
- 水溶性聚合物聚乙二醇会使二棕榈酰磷脂酰胆碱和二棕榈酰磷脂酰乙醇胺水分散体的凝胶 - 液晶相转变温度随浓度增加而升高。2. 对于二棕榈酰磷脂酰胆碱，进一步证明聚乙二醇增加了转变焓和熵，同时降低了转变的协同性。3. 结合聚乙二醇促进细胞融合的可能作用模式对这些结果进行了讨论。
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