维生素A代谢的研究。大鼠体内视黄醛（维生素A醛）的吸收。
Studies on metabolism of vitamin A. Absorption of retinal (vitamin A aldehyde) in rats.
作者信息
Deshmukh D S, Murthy S K, Mahadevan S, Ganguly J
出版信息
Biochem J. 1965 Aug;96(2):377-82. doi: 10.1042/bj0960377.
Abstract
- Young rats with low reserves of vitamin A were dosed with retinal in groundnut oil, and the stomach, the contents, mucosa and muscles of small intestine, the blood and the liver were analysed at periods up to 24hr. after dosing. 2. Up to 6hr. after the dose, retinal was present in high concentrations in the contents, mucosa and muscles of the intestine. Small but significant amounts were present in blood and liver at all times. 3. The intestinal mucosa and muscles always contained small amounts of retinol and its esters. 4. A study of the distribution of the three forms of the vitamin within the mucosal cell showed that most of the mucosal retinal enters the cell unchanged. 5. When protein-depleted rats were similarly given retinal, the rate of reduction of the aldehyde, and the consequent deposition in the liver of retinol and its esters, progressively decreased with reduced protein intake.
摘要
- 给维生素A储备量低的幼鼠喂食花生油中的视黄醛，并在喂食后长达24小时的时间段内，对胃、小肠内容物、黏膜和肌肉、血液以及肝脏进行分析。2. 给药后长达6小时，视黄醛在小肠内容物、黏膜和肌肉中浓度很高。血液和肝脏中始终存在少量但显著的视黄醛。3. 小肠黏膜和肌肉中始终含有少量视黄醇及其酯类。4. 对维生素三种形式在黏膜细胞内分布的研究表明，大部分黏膜视黄醛未发生变化就进入细胞。5. 当给蛋白质缺乏的大鼠同样喂食视黄醛时，醛的还原速率以及随之而来的视黄醇及其酯类在肝脏中的沉积，会随着蛋白质摄入量的减少而逐渐降低。
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