Krammer P H, Pernis B
Scand J Immunol. 1976;5(3):205-12. doi: 10.1111/j.1365-3083.1976.tb00271.x.
The function of Fc receptors (FcR) on mouse spleen cells as detected by a sensitive rosetting system using antibody-labeled bovine erythrocytes as indicator cells was shown to be inhibited by anti-Ia antiserum. Furthermore, the Ia specificities of each I-region sublocus (I-1A, I-1B, I-C) seem to be associated with FrR, since FcR function was also inhibited when the blocking anti-Ia antiserum recognized only restricted Ia specificities. Antiserum directed against antigens coded for by the K-end of the major histocompatibility complex did not inhibit FcR function. The function of C3 receptors and Fc receptors on macrophages and Fc-receptor-positive cells in the fetal liver was not inhibited by anti-Ia antiserum. These findings are discussed in view of a possible arrangement of Fc receptors and Ia antigens on the cell membrane.
通过使用抗体标记的牛红细胞作为指示细胞的敏感玫瑰花结系统检测到，小鼠脾细胞上的Fc受体（FcR）功能被抗Ia抗血清所抑制。此外，每个I区亚位点（I-1A、I-1B、I-C）的Ia特异性似乎与FcR相关，因为当阻断性抗Ia抗血清仅识别有限的Ia特异性时，FcR功能也受到抑制。针对主要组织相容性复合体K端编码抗原的抗血清不会抑制FcR功能。抗Ia抗血清不会抑制胎儿肝脏中巨噬细胞和Fc受体阳性细胞上的C3受体和Fc受体功能。针对细胞膜上Fc受体和Ia抗原的可能排列方式对这些发现进行了讨论。
