Layton H W, Youmans G P
J Bacteriol. 1965 Oct;90(4):958-64. doi: 10.1128/jb.90.4.958-964.1965.
Layton, Herbert W. (Northwestern University Medical School, Chicago, Ill.), and Guy P. Youmans. Effect of dietary factors upon the resistance of albino mice to experimental infection with Mycobacterium tuberculosis. J. Bacteriol. 90:958-964. 1965.-Each of the major nutritional components of a synthetic diet was quantitatively altered to determine its effect upon the resistance of albino mice to infection with Mycobacterium tuberculosis. The animals were challenged after the first 2 weeks of feeding, and the percentage that survived acute death was determined statistically. The level of protein which provided the greatest percentage of survival was 30%; increases or decreases from this level were detrimental. The optimal fat level was found to be 5% for either corn oil or coconut oil. Survival decreased when greater amounts of oil were added, and this effect was especially marked for 40% coconut oil. Vitamin A enhanced survival when increased from the normal level of 20,000 units per kg of diet to 160,000 units, but further increases were harmful. An amount of 75 g/kg of a vitamin B complex mixture afforded optimal resistance, but 25-g shifts in either direction lowered this resistance. Vitamin K-free diets resulted in high levels of survival, and addition of the vitamin resulted in proportional decreases in resistance.
莱顿，赫伯特·W.（伊利诺伊州芝加哥西北大学医学院），以及盖伊·P.尤曼斯。饮食因素对白化小鼠抵抗结核分枝杆菌实验性感染的影响。《细菌学杂志》90:958 - 964。1965年。——对合成饮食的每种主要营养成分进行定量改变，以确定其对白化小鼠抵抗结核分枝杆菌感染的影响。在喂食的前两周后对动物进行攻击，并对急性死亡后存活的百分比进行统计学测定。提供最高存活百分比的蛋白质水平为30%；高于或低于此水平均有害。发现玉米油或椰子油的最佳脂肪水平均为5%。添加更多油时存活率降低，对于40%的椰子油这种影响尤为明显。当维生素A从每千克饮食20,000单位的正常水平增加到160,000单位时，存活率提高，但进一步增加则有害。每千克75克的复合维生素B混合物提供最佳抵抗力，但向任一方向改变25克都会降低这种抵抗力。无维生素K饮食导致高存活率，添加该维生素会使抵抗力成比例下降。
