Youmans G P, Youmans A S
J Bacteriol. 1965 Dec;90(6):1675-81. doi: 10.1128/jb.90.6.1675-1681.1965.
Youmans, Guy P. (Northwestern University Medical School, Chicago, Ill.), and Anne S. Youmans. Nonspecific factors in resistance of mice to experimental tuberculosis. J. Bacteriol. 90:1675-1681. 1965.-In contrast to viable attenuated mycobacterial cells, Escherichia coli lipopolysaccharide (LPS) did not produce an acute pulmonary granulomatous response in mice, did not decrease the tolerance of mice to early subsequent intravenous injections of viable attenuated mycobacterial cells, nor did it increase susceptibility to tuberculous infection when injected simultaneously with virulent mycobacterial cells. When the injection of E. coli LPS was followed by the intravenous injection of virulent mycobacterial cells, there was a moderate increase in resistance to tuberculous infection which was maximal 7 to 14 days after the LPS injection. The degree of increased resistance to tuberculous infection was approximately the same as that produced by nearly maximal tolerated doses of heat-killed attenuated mycobacterial cells, and to that produced by a trichloroacetic acid extract of heat-killed attenuated mycobacterial cells. It is suggested that the major, if not entire, immunizing component of heat-killed attenuated mycobacterial cells resides in a heat-stable "nonspecific" component. A "multiple response" theory of immunity to tuberculosis is proposed.
尤曼斯，盖伊·P.（伊利诺伊州芝加哥西北大学医学院），以及安妮·S.尤曼斯。小鼠对实验性结核病抵抗力中的非特异性因素。《细菌学杂志》90:1675 - 1681。1965年。——与活的减毒分枝杆菌细胞不同，大肠杆菌脂多糖（LPS）在小鼠中不会引发急性肺部肉芽肿反应，不会降低小鼠对随后早期静脉注射活的减毒分枝杆菌细胞的耐受性，并且在与强毒分枝杆菌细胞同时注射时也不会增加对结核感染的易感性。当注射大肠杆菌LPS后接着静脉注射强毒分枝杆菌细胞时，对结核感染的抵抗力会适度增加，在注射LPS后7至14天达到最大值。对结核感染抵抗力增加的程度与几乎最大耐受剂量的热灭活减毒分枝杆菌细胞所产生的程度大致相同，也与热灭活减毒分枝杆菌细胞的三氯乙酸提取物所产生的程度大致相同。有人提出，热灭活减毒分枝杆菌细胞的主要（如果不是全部）免疫成分存在于一种热稳定的“非特异性”成分中。提出了一种针对结核病免疫的“多重反应”理论。
