Burjanová B, Dornetzhuber V
Z Erkr Atmungsorgane. 1975 Jan;142(1):68-77.
Sensitivity of 40 strains of M. kansasii (var. luciflava) to various antibiotics and chemotherapeutics in vitro and in vivo was examined. The strains showed considerable individual variability in their susceptibility in vitro, most were more resistant to isoniazid and PAS and about one half of the investigated strains to streptomycin, too, if correlated to "wild" strains of M. tuberculosis. Susceptibility to ethionamide, thiosemicarbazone (Conteben), viomycin, kanamycin and cycloserine appears to be the same as in the case of M. tuberculosis strains, but the resistance to pyrazinamide is higher. Good effect has been observed in vitro with rifampicin, ethambutol, capreomycin and phenazine derivative B 663. Oleandomycin and gentamycin are ineffectual in the dosages of drugs we used. The activity of most of these drugs was observed in experimental infections of white mice--in mono-therapy and in various combinations-provoked by different strains of M. kansasii. The main criterion of the effectivity of the treatment was the enumeration of viable mycobacterial units in the lungs of the mice in ten-days intervals; in one part of the experiments the histological examination of the various organs of the mice was performed. The drugs of the I. and II. line of antituberculotics were ineffective or showed only a slight effect. A very good effect of rifampicin, ethambutol and phenazine derivative B 663 in monotherapy and in multiply drug therapy was observed.
对40株堪萨斯分枝杆菌（荧光变种）在体外和体内对各种抗生素及化疗药物的敏感性进行了检测。这些菌株在体外敏感性方面表现出相当大的个体差异，与结核分枝杆菌“野生”菌株相比，大多数对异烟肼和对氨基水杨酸耐药，约一半被调查菌株对链霉素也耐药。对乙硫异烟胺、氨硫脲（结核安）、紫霉素、卡那霉素和环丝氨酸的敏感性似乎与结核分枝杆菌菌株情况相同，但对吡嗪酰胺的耐药性更高。在体外观察到利福平、乙胺丁醇、卷曲霉素和吩嗪衍生物B 663有良好效果。我们使用的剂量下，竹桃霉素和庆大霉素无效。在由不同堪萨斯分枝杆菌菌株引发的白色小鼠实验性感染中，观察到了这些药物中的大多数在单一疗法和各种联合疗法中的活性。治疗有效性的主要标准是每隔十天对小鼠肺部活的分枝杆菌单位进行计数；在一部分实验中，对小鼠的各种器官进行了组织学检查。第一线和第二线抗结核药物无效或仅显示出轻微效果。观察到利福平、乙胺丁醇和吩嗪衍生物B 663在单一疗法和多种药物联合疗法中有非常好的效果。
