秋水仙碱和长春花碱对大鼠坐骨神经中胆碱乙酰转移酶轴突运输的影响。
Effects of colchicine and vinblastine on axonal transport of choline acetyltransferase in rat sciatic nerve.
作者信息
Dziegielewska K M, Saunders N R, Evans C A, Skacel P O, Häggendal C J, Heiwall P O, Dahalström A B
出版信息
Acta Physiol Scand. 1976 Apr;96(4):486-94. doi: 10.1111/j.1748-1716.1976.tb10218.x.
The effects of colchicine (0.5-10(-2) M) and vinblastine (10(-2)-10(-5) M) Upon axonal transport of choline acetyltranserase (CAT) and on nerve impulse conduction have been investigated in the rat sciatic nerve. High concentrations of colchicine (0.5 M) and vinblastine (10(-2) M) blocked completely both axonal transport of CAT and impulse conduction. 10(-3) M vinblastine did not affect impulse conduction until 20-22 h after injection, but this concentration of vinblastine did block CAT transport but not impulse conduction. 10(-2) M and 10(-1) M colchicine were without effect on impulse conduction, but did produce substantial, although incomplete, block of CAT transport. The results are discussed in relation to the possible involvement of microtubules in transport of CAT.
已对秋水仙碱（0.5 - 10⁻² M）和长春碱（10⁻² - 10⁻⁵ M）对大鼠坐骨神经中胆碱乙酰转移酶（CAT）轴突运输及神经冲动传导的影响进行了研究。高浓度的秋水仙碱（0.5 M）和长春碱（10⁻² M）完全阻断了CAT的轴突运输和冲动传导。10⁻³ M长春碱在注射后20 - 22小时之前不影响冲动传导，但该浓度的长春碱确实阻断了CAT运输，而未阻断冲动传导。10⁻² M和10⁻¹ M秋水仙碱对冲动传导无影响，但确实对CAT运输产生了显著的（尽管不完全）阻断。结合微管可能参与CAT运输的情况对结果进行了讨论。
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