吲哚美辛与角膜免疫反应。
Indomethacin and the corneal immune response.
作者信息
Belfort R, Smolin G, Hall J M, Okumoto M
出版信息
Am J Ophthalmol. 1976 May;81(5):650-5. doi: 10.1016/0002-9394(76)90132-x.
To study the effect of treating rabbits with a locally administered noncorticosteroid anti-inflammatory drug, we gave 26 rabbits unilateral subconjunctival injections of 15 mg of indomethacin suspension daily for 16 days, starting one day before the intracorneal injection of the same eye with bovine gamma globulin. We graded the eyes clinically and killed groups of rabbits on postimmunization days 6, 9, 12, and 15. We determined the number of antibody-forming cells in the homolateral cervical lymph nodes, corneas, and uveal tracts and tested the sera, aqueous humor, and vitreous humor for antibodies. Indomethacin-treated eyes showed significantly less inflammatory response, and an insignificantly greater number of antibody-forming cells, than the controls.
为研究局部应用非皮质类固醇抗炎药对兔的治疗效果，我们对26只兔进行了如下操作：在其同一只眼的角膜内注射牛γ球蛋白前一天开始，每天对其进行单侧结膜下注射15mg吲哚美辛混悬液，持续16天。我们对兔眼进行临床分级，并在免疫后第6、9、12和15天处死几组兔子。我们测定了同侧颈淋巴结、角膜和葡萄膜中抗体形成细胞的数量，并检测血清、房水和玻璃体液中的抗体。与对照组相比，吲哚美辛治疗的兔眼炎症反应明显减轻，抗体形成细胞数量略有增加。
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