Hall J M, Pribnow J F
Invest Ophthalmol. 1976 Oct;15(10):863-6.
Rabbits injected intravitreally with bovine gamma globulin (BGG) into the right eyes were challenged 3 months later by an intravitreal injection of ovalbumin (OA) into the left eyes. The rabbits were killed 6, 7, and 9 days after challenge and the number of cells producing antibody to both OA and BGG were enumerated. The uveal tract cells of all left eyes produced anti-BGG even though no BGG had been injected into the left eyes. The uveal tract response to OA was less pronounced and typical of a primary response. High anti-BGG titers were found in the aqueous and vitreous humors of the left eyes of many of the rabbits. The reasons for this apparently non-specific stimulation of a secondary response in the absence of specific antigenic challenge are discussed.
给兔右眼玻璃体内注射牛γ球蛋白（BGG），3个月后给左眼玻璃体内注射卵清蛋白（OA）进行激发。激发后6、7和9天处死兔子，计数产生针对OA和BGG抗体的细胞数量。尽管左眼未注射BGG，但所有左眼的葡萄膜细胞均产生抗BGG。葡萄膜对OA的反应不那么明显，属于典型的初次反应。许多兔子左眼的房水和玻璃体液中发现了高抗BGG滴度。讨论了在没有特异性抗原激发的情况下这种对二次反应的明显非特异性刺激的原因。
