Triner L, Nahas G G
Science. 1965 Dec 24;150(3704):1725-7. doi: 10.1126/science.150.3704.1725.
Lowering of pH from 7.40 to 6.60 significantly decreased the rate of glycerol formation in fat cells incubated with either 1-norepinephrine or theophylline. When these cells were incubated with both 1-norepinephrine and theophylline, the glycerol formation proceeded at maximal rate and was quite similar at pH 7.40 and 6.60. These results indicate that the inhibitory effect of acidosis on the lipolytic action of 1-norepinephrine is exerted on the process which activates lipase.
将pH从7.40降至6.60，显著降低了用1-去甲肾上腺素或茶碱孵育的脂肪细胞中甘油生成的速率。当这些细胞同时用1-去甲肾上腺素和茶碱孵育时，甘油生成以最大速率进行，且在pH 7.40和6.60时非常相似。这些结果表明，酸中毒对1-去甲肾上腺素脂解作用的抑制作用是在激活脂肪酶的过程中发挥的。
