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Investigation into the metabolic fate of orphenadrine hydrochloride after oral administration to male rats.

作者信息

Hespe W, de Roos A M, Nauta W T

出版信息

Arch Int Pharmacodyn Ther. 1965 Jul;156(1):180-200.

PMID:5858833
Abstract
摘要

相似文献

1
Investigation into the metabolic fate of orphenadrine hydrochloride after oral administration to male rats.对雄性大鼠口服盐酸邻甲苯海明后代谢命运的研究。
Arch Int Pharmacodyn Ther. 1965 Jul;156(1):180-200.
2
Metabolic studies of 3 H-orphenadrine citrate in the rat, dog and rhesus monkey.
Arch Int Pharmacodyn Ther. 1972 Feb;195(2):213-30.
3
Autoradiographic study of the distribution of radioactivity in mice after oral administration of tritium-labelled orphenadrine hydrochloride.
Arch Int Pharmacodyn Ther. 1968 Jan;171(1):47-57.
4
Evidence for side-chain degradation of orphenadrine HCl in the rat.盐酸奥芬那君在大鼠体内侧链降解的证据。
Biochem Pharmacol. 1967 Sep 9;16(9):1847-8. doi: 10.1016/0006-2952(67)90262-6.
5
The concentrations of orphenadrine and its N-demethylated derivatives in rat brain, after intraperitoneal administration of orphenadrine and tofenacine.腹腔注射邻甲苯海明和托芬那辛后，大鼠脑中邻甲苯海明及其N-去甲基化衍生物的浓度。
Int J Neuropharmacol. 1968 May;7(3):293-300. doi: 10.1016/0028-3908(68)90036-1.
6
Product inhibition in orphenadrine metabolism as a result of a stable cytochrome P-450-metabolic intermediate complex formed during the disposition of mono-N-desmethylorphenadrine (tofenacine) in the rat.在大鼠体内单-N-去甲基邻甲苯海明（托非那辛）代谢过程中形成稳定的细胞色素P-450代谢中间复合物，导致邻甲苯海明代谢出现产物抑制现象。
Res Commun Chem Pathol Pharmacol. 1983 Jun;40(3):391-403.
7
Aspects of the biliary excretion of orphenadrine and its N-demethylated derivative, tofenacin, in the rat.去痛片及其N-去甲基衍生物托芬那辛在大鼠体内的胆汁排泄情况。
Eur J Pharmacol. 1970;13(1):113-22. doi: 10.1016/0014-2999(70)90191-3.
8
Metabolism of orphenadrine citrate in man.
J Pharmacol Exp Ther. 1971 Feb;176(2):284-95.
9
Distribution of tritium-labelled tofenacine hydrochloride in the pregnant mouse.氚标记盐酸托芬那辛在妊娠小鼠体内的分布
Eur J Pharmacol. 1969 Oct;8(1):119-26. doi: 10.1016/0014-2999(69)90137-x.
10
Metabolic fate of the new angiotensin-converting enzyme inhibitor imidapril in animals. 3rd communication: tissue accumulation after consecutive oral administration of [N-methyl-14C]-imidapril in rats.新型血管紧张素转换酶抑制剂咪达普利在动物体内的代谢命运。第三次通讯：大鼠连续口服[N-甲基-14C] -咪达普利后的组织蓄积
Arzneimittelforschung. 1992 Apr;42(4):475-82.

引用本文的文献

1
Difference between single and multiple dose pharmacokinetics of orphenadrine hydrochloride in man.
Eur J Clin Pharmacol. 1982;21(4):343-50. doi: 10.1007/BF00637624.
2
Effect of multiple administration of orphenadrine or mono-N-desmethylorphenadrine on cytochrome P-450 catalyzed reactions in the rat.多次给予奥芬那君或单-N-去甲基奥芬那君对大鼠细胞色素P-450催化反应的影响。
Arch Toxicol. 1983 Oct;54(2):131-7. doi: 10.1007/BF01261381.
3
[On anatomical and chemotoxicologic findings in a case of lethal poisoning by orphenadrine].[关于一例因邻甲苯海明致死性中毒的解剖学和化学毒理学发现]
Arch Toxikol. 1969;25(1):76-82.
4
Lethal orphenadrine intoxications. A report of five cases.致死性邻甲苯海明中毒。五例报告。
Z Rechtsmed. 1971;68(2):111-4. doi: 10.1007/BF02116214.