[Paraproteinemia in chronic lymphocytic leukemia].

In 10 from 305 patients affected with chronic lymphatic leukaemia a paraprotein was identified by paper electrophoresis in the blood, namely IgG 5 times, IgM 3 times, IgA once and 2 paraproteins IgG and IgM once. The paraprotein content laid between 0.24 and 2.0 g %. During a long-time observation the paraprotein concentrations varied only insignificantly and independently of the number of lymphocytes. In one patient M-gradient disappaered after 2 years. In 8 patients protein could be proved in the urine, in 5 of them 25-65% of the urine protein consisted of light chains. The course of the disease in these patients affected with paraproteinaemia scarcely differed from those patients without this protein anomaly. The conclusion may be drawn from this that the cell clon producing paraprotein is little aggressive.