Roitman I, Anghinah A
Arq Neuropsiquiatr. 1977 Dec;35(4):354-61. doi: 10.1590/s0004-282x1977000400008.
Using the clinical quantification of the neurologic symptomatology the authors made observations and avaliated the action of Ciba 34.647-Ba, a GABA derivative, in 12 patients suffering from spasticity and motor incapacity due to spinal cord lesions. The results are reported emphasizing the effects of the drug on the main components of spasticity (hypertonus, hyperactivity of the deep reflexes, clonus and automatisms). Some theories explaining the mechanism of action of the drug are mentioned. References are made about doses, duration of action, tolerance and side-effects.
作者运用神经症状学的临床量化方法,对12例因脊髓损伤导致痉挛和运动功能丧失的患者进行了观察,并评估了一种γ-氨基丁酸衍生物——西巴34647-Ba的作用。报告了该药物对痉挛主要成分(张力亢进、深反射亢进、阵挛和自动症)的影响,并提及了一些解释该药物作用机制的理论。还介绍了药物的剂量、作用持续时间、耐受性和副作用。