Jones R F, Lance J W
Med J Aust. 1976 May 1;1(18):654-7. doi: 10.5694/j.1326-5377.1976.tb140942.x.
This report summarizes experience with baclofen (Lioresal) in the management of spasticity and muscle spasms in 113 patients treated for up to six years. Baclofen was found to be of little help in nine patients with spasticity of cerebral origin, but was effective in reducing spasticity of spinal origin in 72 out of 90 patients (80%). It also reduced the number and severity of spasms in 76 out of 87 patients (87%). Side effects necessitating reduction of dosage were experienced by 20% of patients. Baclofen appears to be a safe and effective agent in the management of spasticity, with the advantage that adequate dosage can usually be achieved without sedation. Beneficial effects have persisted throughout the follow-up period.
本报告总结了113例接受巴氯芬（力奥来素）治疗长达6年的患者在痉挛和肌肉痉挛管理方面的经验。发现巴氯芬对9例脑源性痉挛患者帮助不大，但在90例患者中有72例（80%）对减轻脊髓源性痉挛有效。它还使87例患者中的76例（87%）痉挛次数和严重程度减少。20%的患者出现需要减少剂量的副作用。巴氯芬在痉挛管理方面似乎是一种安全有效的药物，优点是通常无需镇静就能达到足够剂量。在整个随访期间，有益效果一直持续。
