Titchen D A, Anderson N
Aust Vet J. 1977 Aug;53(8):369-73. doi: 10.1111/j.1751-0813.1977.tb07953.x.
Sheep and calves prepared with separated, innervated pouches made from the acid secreting region of the abomasum were given single or multiple infections of Ostertagia spp and comparisons were made of the secretory changes of parasitised and non-parasitised mucosa by means of cannulas placed in the abomasum and pouch. Contrary reactions of the parasite-free pouches and infected main part of the abomasum are described and explained in terms of a two-part hypothesis. The inhibitory effect on acid secretion of the abomasum (resulting in its contents being pH 5 to 7) was postulated to be due to the direct suppressive effects of substances released locally by parasites or injured host tissues, whereas increased secretion of the hormone, gastrin, was thought to account for the stimulatory effects of infection on acid secretion from the pouches. In sheep treated with anthelmintic and then reinfected the inhibitory effects on abomasal pH were not obtained. The hypersecretion from the pouches still persisted.
用取自皱胃泌酸区的分离、带神经支配的小袋制备绵羊和小牛，使其单次或多次感染奥斯特他属线虫，并通过置于皱胃和小袋中的插管，比较寄生和未寄生黏膜的分泌变化。根据一个两部分假说，描述并解释了无寄生虫小袋和感染的皱胃主要部分的相反反应。推测对皱胃酸分泌的抑制作用（导致其内容物pH值为5至7）是由于寄生虫或受损宿主组织局部释放的物质的直接抑制作用，而激素胃泌素分泌增加被认为是感染对小袋酸分泌产生刺激作用的原因。在用驱虫药治疗然后再次感染的绵羊中，未观察到对皱胃pH值的抑制作用。小袋的分泌亢进仍然持续存在。
