Analogs of tetrahydrofolic acid XX. Effects of modification of the bridge between the pyrimidyl and phenyl moieties of 2-amino-5-(3-anilinopropyl)-6-methyl-4-pyrimidinol on inhibition of dihydrofolic reductase and thymidylate synthetase II.
作者信息
Baker B R, Ho B T
出版信息
J Pharm Sci. 1965 Aug;54(8):1187-90. doi: 10.1002/jps.2600540820.
PMID:5882225
Abstract
摘要
相似文献
1
Analogs of tetrahydrofolic acid XX. Effects of modification of the bridge between the pyrimidyl and phenyl moieties of 2-amino-5-(3-anilinopropyl)-6-methyl-4-pyrimidinol on inhibition of dihydrofolic reductase and thymidylate synthetase II.四氢叶酸类似物XX。2-氨基-5-(3-苯胺基丙基)-6-甲基-4-嘧啶醇嘧啶基和苯基部分之间桥的修饰对二氢叶酸还原酶和胸苷酸合成酶抑制作用的影响II。
J Pharm Sci. 1965 Aug;54(8):1187-90. doi: 10.1002/jps.2600540820.
2
Analogs of tetrahydrofolic acid XXIV. Further observations on the mode of pyrimidyl binding to dihydrofolic reductase and thymidylate synthetase by the 2-amino-5-(3-anilinopropyl)-6-methyl-4-pyrimidinol type of inhibitor.四氢叶酸类似物XXIV。关于2-氨基-5-（3-苯胺基丙基）-6-甲基-4-嘧啶醇类抑制剂与二氢叶酸还原酶和胸苷酸合成酶结合嘧啶基方式的进一步观察。
J Pharm Sci. 1965 Sep;54(9):1252-7. doi: 10.1002/jps.2600540905.
3
Analogs of tetrahydrofolic acid XXII. Effects of modification of the bridge between the pyrimidyl and phenyl moieties of 2-amino-5-(3-anilinopropyl)-6-methyl-4-pyrimidinol thymidylate synthetase. 3.四氢叶酸类似物XXII。2-氨基-5-(3-苯胺基丙基)-6-甲基-4-嘧啶醇胸苷酸合成酶嘧啶基和苯基部分之间桥修饰的影响。3。
J Pharm Sci. 1965 May;54(5):714-9. doi: 10.1002/jps.2600540511.
4
ANALOGS OF TETRAHYDROFOLIC ACID. XIV. FACILE SYNTHETIC ROUTE TO THE 2-AMINO-5-(3-ANILINOPROPYL)-6-METHYL-4-PYRIMIDINOL TYPE OF FOLIC REDUCTASE AND THYMIDYLATE SYNTHETASE INHIBITOR.四氢叶酸类似物。十四。通往2-氨基-5-（3-苯胺基丙基）-6-甲基-4-嘧啶醇类叶酸还原酶和胸苷酸合成酶抑制剂的简便合成路线。
J Pharm Sci. 1964 Nov;53:1317-25. doi: 10.1002/jps.2600531107.
5
Analogs of tetrahydrofolic acid XXV. 2,4-Diamino-6-phenethylpteridine, an inhibitor of dihydrofolic reductase.四氢叶酸类似物XXV。2,4-二氨基-6-苯乙基蝶啶，一种二氢叶酸还原酶抑制剂。
J Pharm Sci. 1965 Sep;54(9):1261-5. doi: 10.1002/jps.2600540907.
6
Inhibition of thymidylate synthetase by some analogs of tetrahydrofolic acid.某些四氢叶酸类似物对胸苷酸合成酶的抑制作用。
Mol Pharmacol. 1967 Jul;3(4):370-7.
7
ANALOGS OF TETRAHYDROFOLIC ACID. XVII. ON THE MODE OF BINDING OF THE P-AMINOBENZOYL MOIETY OF N-(2-AMINO-4-HYDROXY-6-METHYL-5-PYRIMIDYLPROPYL)-P-AMINOBENZOYL-L-GLUTAMIC ACID TO DIHYDROFOLIC REDUCTASE.四氢叶酸类似物。十七。关于N-（2-氨基-4-羟基-6-甲基-5-嘧啶基丙基）-对氨基苯甲酰-L-谷氨酸的对氨基苯甲酰部分与二氢叶酸还原酶的结合方式
J Med Chem. 1965 Jan;8:35-41. doi: 10.1021/jm00325a009.
8
Analogs of tetrahydrofolic acid 34. Hydrophobic bonding to dihydrofolic reductase VI. Mode of phenyl binding of some 6-arylpyrimidines.四氢叶酸类似物34。与二氢叶酸还原酶的疏水结合VI。一些6-芳基嘧啶的苯基结合模式。
J Pharm Sci. 1966 Mar;55(3):308-17. doi: 10.1002/jps.2600550309.
9
Analogs of tetrahydrofolic acid. 33. Hydrophobic bonding to dihydrofolic reductase V. Inhibition by some pyrimidines bridged to benzoic acid.四氢叶酸类似物。33. 与二氢叶酸还原酶V的疏水键合。一些与苯甲酸桥连的嘧啶的抑制作用。
J Pharm Sci. 1966 Mar;55(3):302-8. doi: 10.1002/jps.2600550308.
10
Analogs of tetrahydrofolic acid. XXVII. Hydrophobic bonding to dihydrofolic reductase by 2-amino-4,6-disubstituted-5-alkylpyrimidines and 1-alkyl-4,6-diamino-1,2-dihydro-s-triazines.四氢叶酸类似物。XXVII. 2-氨基-4,6-二取代-5-烷基嘧啶和1-烷基-4,6-二氨基-1,2-二氢-s-三嗪与二氢叶酸还原酶的疏水键合作用
J Pharm Sci. 1965 Oct;54(10):1415-24. doi: 10.1002/jps.2600541005.
Zotero 插件