Analogs of tetrahydrofolic acid. 33. Hydrophobic bonding to dihydrofolic reductase V. Inhibition by some pyrimidines bridged to benzoic acid.
作者信息
Baker B R, Ho B T, Coward J K, Santi D V
出版信息
J Pharm Sci. 1966 Mar;55(3):302-8. doi: 10.1002/jps.2600550308.
PMID:5960176
Abstract
摘要
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1
Analogs of tetrahydrofolic acid. 33. Hydrophobic bonding to dihydrofolic reductase V. Inhibition by some pyrimidines bridged to benzoic acid.四氢叶酸类似物。33. 与二氢叶酸还原酶V的疏水键合。一些与苯甲酸桥连的嘧啶的抑制作用。
J Pharm Sci. 1966 Mar;55(3):302-8. doi: 10.1002/jps.2600550308.
2
Analogs of tetrahydrofolic acid 34. Hydrophobic bonding to dihydrofolic reductase VI. Mode of phenyl binding of some 6-arylpyrimidines.四氢叶酸类似物34。与二氢叶酸还原酶的疏水结合VI。一些6-芳基嘧啶的苯基结合模式。
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Analogs of tetrahydrofolic acid. 32. Hydrophobic bonding to dihydrofolic reductase IV. Inhibition by p-substituted benzoic and benzoyl-L-glutamic acids.四氢叶酸类似物。32. 与二氢叶酸还原酶IV的疏水键合。对对位取代苯甲酸和苯甲酰-L-谷氨酸的抑制作用。
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4
Analogs of tetrahydrofolic acid. XXVII. Hydrophobic bonding to dihydrofolic reductase by 2-amino-4,6-disubstituted-5-alkylpyrimidines and 1-alkyl-4,6-diamino-1,2-dihydro-s-triazines.四氢叶酸类似物。XXVII. 2-氨基-4,6-二取代-5-烷基嘧啶和1-烷基-4,6-二氨基-1,2-二氢-s-三嗪与二氢叶酸还原酶的疏水键合作用
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Analogs of tetrahydrofolic acid XXV. 2,4-Diamino-6-phenethylpteridine, an inhibitor of dihydrofolic reductase.四氢叶酸类似物XXV。2,4-二氨基-6-苯乙基蝶啶，一种二氢叶酸还原酶抑制剂。
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Analogs of tetrahydrofolic acid XX. Effects of modification of the bridge between the pyrimidyl and phenyl moieties of 2-amino-5-(3-anilinopropyl)-6-methyl-4-pyrimidinol on inhibition of dihydrofolic reductase and thymidylate synthetase II.四氢叶酸类似物XX。2-氨基-5-(3-苯胺基丙基)-6-甲基-4-嘧啶醇嘧啶基和苯基部分之间桥的修饰对二氢叶酸还原酶和胸苷酸合成酶抑制作用的影响II。
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7
Irreversible enzyme inhibitors. 88. Differential irreversible inhibition of dihydrofolic reductase from different species.不可逆酶抑制剂。88. 不同物种二氢叶酸还原酶的差异性不可逆抑制作用。
J Pharm Sci. 1967 May;56(5):660-1. doi: 10.1002/jps.2600560532.
8
Analogs of tetrahydrofolic acid XXIV. Further observations on the mode of pyrimidyl binding to dihydrofolic reductase and thymidylate synthetase by the 2-amino-5-(3-anilinopropyl)-6-methyl-4-pyrimidinol type of inhibitor.四氢叶酸类似物XXIV。关于2-氨基-5-（3-苯胺基丙基）-6-甲基-4-嘧啶醇类抑制剂与二氢叶酸还原酶和胸苷酸合成酶结合嘧啶基方式的进一步观察。
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9
Irreversible enzyme inhibitors. LXXI. Candidate active-site-directed irreversible inhibitors of dihydrofolic reductase. V. Derivatives of 6-phenylpyrimidine.不可逆酶抑制剂。第七十一部分。二氢叶酸还原酶潜在的活性位点导向不可逆抑制剂。第五章。6-苯基嘧啶衍生物。
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10
Irreversible enzyme inhibitors. LXXXII. Candidate active-site-directed irreversible inhibitors of dihydrofolic reductase. VII. Derivatives of 2,4-diaminopyrimidine. I.不可逆酶抑制剂。八十二。二氢叶酸还原酶的候选活性位点导向不可逆抑制剂。七。2,4-二氨基嘧啶的衍生物。一。
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