Nooney G C
Biophys J. 1965 Nov;5(6):755-65. doi: 10.1016/S0006-3495(65)86750-9.
The mathematical model of steady-state iron kinetics in the human presented here extends the use of radioactive tracer observations in the determination of erythron maturative and proliferative behavior. Functions descriptive of that behavior appear explicitly in the model together with functions customarily measured in standard tracer procedures. The model is compartmental, with transfers compatible with all observed erythropoietic and hemolytic mechanisms as well as with most plausible conjunctured mechanisms. Obtainable from the model is quantitative information about iron uptake, intermitotic intervals, and maturation time of erythrons; about intra- and extramedullary hemolysis; and about certain standard exchange rates. The model also permits tests of competing conjectures about erythron behavior.
本文提出的人体稳态铁动力学数学模型扩展了放射性示踪观察在确定红细胞生成和增殖行为方面的应用。描述该行为的函数与标准示踪程序中通常测量的函数一起明确出现在模型中。该模型是 compartmental 的，其转移与所有观察到的红细胞生成和溶血机制以及最合理的推测机制兼容。从该模型中可以获得有关铁摄取、红细胞有丝分裂间期和成熟时间的定量信息；有关髓内和髓外溶血的信息；以及有关某些标准交换率的信息。该模型还允许对关于红细胞行为的相互竞争的推测进行测试。 （注：“compartmental”这个词可能有误，不太明确准确意思，暂按原文翻译）
