Biophys J. 1966 Sep;6(5):601-9. doi: 10.1016/S0006-3495(66)86680-8.
The mathematical model here presented of steady-state iron kinetics in the human explicitly displays the influence of the maturative and proliferative behavior of erythrons (erythrocytes or their precursory cells). Based on a compartmented iron kinetics scheme, the model is in the form of a system of linear integrodifferential equations and describes the distribution of administered radioactive tracer as a function of time. Erythron behavior is characterized by three functions specifying iron uptake, proliferation, and survival. Simulative uses of the model are discussed and illustrated by an example.
这里提出的人类稳态铁动力学数学模型明确显示了红细胞(或其前体细胞)成熟和增殖行为的影响。基于分区铁动力学方案,该模型为线性积分微分方程组的形式,并描述了放射性示踪剂给药的分布随时间的变化。红细胞行为由指定铁摄取、增殖和存活的三个函数来表征。通过一个示例讨论了模型的模拟应用并进行了说明。