ICRF 159与辐射的相互作用及其对体外亚致死性和潜在致死性辐射损伤的影响。
Interaction of ICRF 159 with radiation, and its effect on sub-lethal and potentially lethal radiation damage in vitro.
作者信息
Taylor I W, Bleehen N M
出版信息
Br J Cancer. 1977 Oct;36(4):493-500. doi: 10.1038/bjc.1977.219.
Abstract
ICRF 159 has been shown to increase the X-radiation sensitivity of exponentially growing EMT6 mouse tumour cells in vitro. This was found only with ICRF 159 exposure times longer than 10 h and only when the drug was given before irradiation. The increase in radiation sensitivity was expressed as a reduction of the shoulder of the radiation survival curve. As ICRF 159 was shown to have no effect on the repair of sub-lethal radiation damage, it was concluded that the drug reduced the capacity to accumulate such damage. ICRF 159 was also shown to have no effect on the repair of potentially lethal radiation damage in late plateau cells.
摘要
已证明ICRF 159可提高体外指数生长的EMT6小鼠肿瘤细胞对X射线的敏感性。仅在ICRF 159暴露时间超过10小时且仅在照射前给予该药物时才发现这种情况。辐射敏感性的增加表现为辐射存活曲线肩部的降低。由于已证明ICRF 159对亚致死性辐射损伤的修复没有影响，因此得出结论，该药物降低了积累此类损伤的能力。还证明ICRF 159对晚期平台期细胞中潜在致死性辐射损伤的修复没有影响。
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