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1
Interaction of ICRF 159 with radiation, and its effect on sub-lethal and potentially lethal radiation damage in vitro.ICRF 159与辐射的相互作用及其对体外亚致死性和潜在致死性辐射损伤的影响。
Br J Cancer. 1977 Oct;36(4):493-500. doi: 10.1038/bjc.1977.219.
2
Changes in sensitivity to radiation and ICRF 159 during the life of monolayer cultures of EMT6 tumour line.EMT6肿瘤细胞系单层培养过程中对辐射和ICRF 159敏感性的变化。
Br J Cancer. 1977 May;35(5):587-94. doi: 10.1038/bjc.1977.92.
3
Radiation survival properties of cultured human gastric adenocarcinoma cells and the effect of AT-1727.培养的人胃腺癌细胞的辐射存活特性及AT-1727的作用
Int J Radiat Oncol Biol Phys. 1989 Feb;16(2):361-8.
4
Biological properties of ICRF-159 and related bis(dioxopiperazine) compounds.ICRF-159及相关双（二氧代哌嗪）化合物的生物学特性。
Adv Pharmacol Chemother. 1982;19:249-90. doi: 10.1016/s1054-3589(08)60025-3.
5
Interaction of razoxane and radiation on cultured Chinese hamster cells.丙亚胺与辐射对培养的中国仓鼠细胞的相互作用。
Int J Radiat Oncol Biol Phys. 1982 Aug;8(8):1333-8. doi: 10.1016/0360-3016(82)90583-1.
6
Interaction of radiation and AT 1727 in HeLa S-3 cells in culture.
Int J Radiat Oncol Biol Phys. 1985 Jun;11(6):1137-42. doi: 10.1016/0360-3016(85)90061-6.
7
ICRF-159 enhancement of radiation response in combined modality therapies. II. Differential responses of tumour and normal tissues.ICRF - 159在综合治疗中增强辐射反应。II. 肿瘤组织与正常组织的不同反应。
Br J Cancer. 1979 May;39(5):524-30. doi: 10.1038/bjc.1979.96.
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Reduction by ICRF-187 of acute daunorubicin toxicity in Syrian golden hamsters.ICRF-187减轻叙利亚金黄地鼠急性柔红霉素毒性的作用
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9
The cytokinetic and cytotoxic effects of ICRF-159 and ICRF-187 in vitro and ICRF-187 in human bone marrow in vivo.ICRF - 159和ICRF - 187的体外细胞动力学及细胞毒性作用以及ICRF - 187在人体骨髓中的体内作用。
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10
Effects of the L isomer (+)-1,2-bis(3,5-dioxopiperazine-1-yl)propane on cell survival and cell cycle progression of cultured mammalian cells.L-异构体（+）-1,2-双（3,5-二氧代哌嗪-1-基）丙烷对培养的哺乳动物细胞存活及细胞周期进程的影响。
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引用本文的文献

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Metal binding by pharmaceuticals. Part 2. Interactions of Ca(II), Cu(II), Fe(II), Mg(II), Mn(II) and Zn(II) with the intracellular hydrolysis products of the antitumour agent ICRF 159 and its inactive homologue ICRF 192.药物与金属的结合。第2部分。Ca(II)、Cu(II)、Fe(II)、Mg(II)、Mn(II)和Zn(II)与抗肿瘤药物ICRF 159及其无活性同系物ICRF 192的细胞内水解产物的相互作用。
Agents Actions. 1982 Oct;12(4):536-42. doi: 10.1007/BF01965940.
2
ICRF-159 enhancement of radiation response in combined modality therapies. II. Differential responses of tumour and normal tissues.ICRF - 159在综合治疗中增强辐射反应。II. 肿瘤组织与正常组织的不同反应。
Br J Cancer. 1979 May;39(5):524-30. doi: 10.1038/bjc.1979.96.
3
ICRF-159 enhancement of radiation response in combined modality therapies. I. Time/dose relationships for tumour response.ICRF - 159对联合治疗中放射反应的增强作用。I. 肿瘤反应的时间/剂量关系。
Br J Cancer. 1979 May;39(5):516-23. doi: 10.1038/bjc.1979.95.

本文引用的文献

1
X-ray damage and recovery in mammalian cells in culture.培养的哺乳动物细胞中的X射线损伤与恢复
Nature. 1959 Oct 24;184:1293-5. doi: 10.1038/1841293a0.
2
Failure of Chinese hamster cells to repair sub-lethal damage when x-irradiated in the plateau phase of growth.中国仓鼠细胞在生长的平台期经X射线照射后无法修复亚致死损伤。
Nature. 1968 Feb 24;217(5130):741-2. doi: 10.1038/217741a0.
3
Potentiation of x-ray killing by 5-bromodeoxyuridine in Chinese hamster cells: a reduction in capacity for sublethal damage accumulation.5-溴脱氧尿苷对中国仓鼠细胞X射线杀伤的增强作用：亚致死损伤积累能力的降低
Radiat Res. 1971 Aug;47(2):437-49.
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Repair of sub-lethal and potentially lethal radiation damage in plateau phase cultures of human cells.人细胞平台期培养物中亚致死性和潜在致死性辐射损伤的修复
Nature. 1969 Nov 22;224(5221):804-6. doi: 10.1038/224804a0.
5
Repair of potentially lethal lesions in x-irradiated, density-inhibited Chinese hamster cells: metabolic effects and hypoxia.X射线照射、密度抑制的中国仓鼠细胞中潜在致命损伤的修复：代谢效应与缺氧
Radiat Res. 1973 Aug;55(2):280-90.
6
Repair of potentially lethal radiation damage in vitro and in vivo.体内外潜在致死性辐射损伤的修复
Radiology. 1973 Mar;106(3):689-94. doi: 10.1148/106.3.689.
7
Plateau-phase cultures of mammalian cells: an in vitro model for human cancer.哺乳动物细胞的平台期培养：一种人类癌症的体外模型。
Curr Top Radiat Res Q. 1972 Jul;8(1):39-43.
8
Synergism of ICRF 159 and radiotherapy in treatment of experimental tumors.ICRF 159与放射疗法在实验性肿瘤治疗中的协同作用。
Cancer. 1974 Oct;34(4):1033-9. doi: 10.1002/1097-0142(197410)34:4<1033::aid-cncr2820340412>3.0.co;2-0.
9
Combined treatment of the Walker tumour with radiotherapy and ICRF 159.沃克肿瘤的放射治疗与ICRF 159联合治疗
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1974;82(4):329-34. doi: 10.1007/BF00285567.
10
Repair of potentially lethal damage in x-irradiated HeLa cells.X射线照射的HeLa细胞中潜在致死性损伤的修复
Radiat Res. 1966 Nov;29(3):413-32.

ICRF 159与辐射的相互作用及其对体外亚致死性和潜在致死性辐射损伤的影响。

Interaction of ICRF 159 with radiation, and its effect on sub-lethal and potentially lethal radiation damage in vitro.

作者信息

Taylor I W, Bleehen N M

出版信息

Br J Cancer. 1977 Oct;36(4):493-500. doi: 10.1038/bjc.1977.219.

DOI:10.1038/bjc.1977.219
PMID:588416
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2025374/
Abstract

ICRF 159 has been shown to increase the X-radiation sensitivity of exponentially growing EMT6 mouse tumour cells in vitro. This was found only with ICRF 159 exposure times longer than 10 h and only when the drug was given before irradiation. The increase in radiation sensitivity was expressed as a reduction of the shoulder of the radiation survival curve. As ICRF 159 was shown to have no effect on the repair of sub-lethal radiation damage, it was concluded that the drug reduced the capacity to accumulate such damage. ICRF 159 was also shown to have no effect on the repair of potentially lethal radiation damage in late plateau cells.

摘要

已证明ICRF 159可提高体外指数生长的EMT6小鼠肿瘤细胞对X射线的敏感性。仅在ICRF 159暴露时间超过10小时且仅在照射前给予该药物时才发现这种情况。辐射敏感性的增加表现为辐射存活曲线肩部的降低。由于已证明ICRF 159对亚致死性辐射损伤的修复没有影响，因此得出结论，该药物降低了积累此类损伤的能力。还证明ICRF 159对晚期平台期细胞中潜在致死性辐射损伤的修复没有影响。