Bochenek W J, Rodgers J B
Biochim Biophys Acta. 1977 Dec 21;489(3):503-6. doi: 10.1016/0005-2760(77)90170-9.
Nonionic detergents were found to affect absorption of neutral lipid and cholesterol. The effects of these detergents were related to their physicochemical properties. The most effective detergents for producing an inhibition of lipid absorption were detergents containing 90% hydrophobic components. Hydrophilic detergents did not interfere with lipid absorption and in some cases, it was facilitated. Studies done over a period of one month demonstrate that addition of a hydrophobic detergent to a high fat-high cholesterol diet results in lower serum levels of cholesterol and triglyceride and prevents cholesterol accumulation in the liver of the rat. This effect was also associated with significant loss of body weight.
已发现非离子洗涤剂会影响中性脂质和胆固醇的吸收。这些洗涤剂的作用与其物理化学性质有关。对脂质吸收产生抑制作用最有效的洗涤剂是含有90%疏水成分的洗涤剂。亲水性洗涤剂不会干扰脂质吸收，在某些情况下，还会促进脂质吸收。为期一个月的研究表明，在高脂肪高胆固醇饮食中添加疏水洗涤剂会降低大鼠血清中的胆固醇和甘油三酯水平，并防止胆固醇在大鼠肝脏中积累。这种作用还与体重显著减轻有关。
