Spira A, Philippe E, Spira N, Dreyfus J, Schwartz D
Biomedicine. 1977 Oct;27(7):266-70.
The pathological study of all placentas from women smoking at least five cigarettes daily during pregnancy (248 cases) and of those placentas from a corresponding control group randomised among all the non-smokers (196 cases) has been set up at the maternity hospital of Haguenau (France) since 1974. The systematic histological examination has shown among smokers a higher frequency of abonormal trophoblast and especially of nuclear clumps in the syncytiotrophoblast. On the other hand, according to a standard protocol, the grouping of various abnormalities has shown, among smokers, a higher frequency of "signs of hypoxia". The lack of relationship between these "signs of hypoxia" and the well-known decreased birthweight among smokers suggests that smoking during pregnancy could always go with a decreased birthweight without a corresponding decreased placental weight, and seldom with an intra-uterine hypoxia. These two effects are independent.
自1974年起，法国阿格诺妇产医院对孕期每天至少吸食5支香烟的女性所产的全部胎盘（248例）以及在所有非吸烟者中随机选取的相应对照组的胎盘（196例）进行了病理学研究。系统的组织学检查显示，吸烟者中滋养层异常尤其是合体滋养层核团的出现频率更高。另一方面，根据标准方案，对各种异常情况进行分组后发现，吸烟者中“缺氧迹象”的出现频率更高。这些“缺氧迹象”与吸烟者中众所周知的出生体重下降之间缺乏关联，这表明孕期吸烟可能总是伴随着出生体重下降，而胎盘重量却没有相应减轻，且很少伴有宫内缺氧。这两种影响是相互独立的。
