狄氏剂对大鼠肝脏溶酶体稳定性的影响。
Effect of dieldrin on the stability of lysosomes in the rat liver.
作者信息
Kohli K K, Siddiqui F A, Venkitasubramanian T A
出版信息
Bull Environ Contam Toxicol. 1977 Nov;18(5):617-23. doi: 10.1007/BF01684009.
PMID:588771
Abstract
The effect of dieldrin on the bound and free activity of cathepsin, acid ribonuclease, acid phosphatase and aryl sulphatase has been investigated. Administration of dieldrin increased the activity of free cathepsin, acid ribonuclease, and acid phosphatase in rat liver whereas it did not affect the activity of aryl sulphatase. This indicates that dieldrin labilizes the lysosomes.
摘要
已对狄氏剂对组织蛋白酶、酸性核糖核酸酶、酸性磷酸酶和芳基硫酸酯酶的结合活性和游离活性的影响进行了研究。给大鼠施用狄氏剂可增加其肝脏中游离组织蛋白酶、酸性核糖核酸酶和酸性磷酸酶的活性，而对芳基硫酸酯酶的活性没有影响。这表明狄氏剂会使溶酶体不稳定。
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