大鼠中可卡因和苯丙胺辨别性刺激特性的比较。
Comparison of the discriminative stimulus properties of cocaine and amphetamine in rats.
作者信息
D'Mello G D, Stolerman I P
出版信息
Br J Pharmacol. 1977 Nov;61(3):415-22. doi: 10.1111/j.1476-5381.1977.tb08434.x.
Abstract
- Water-deprived rats were trained to press either the left or the right bar in a test chamber according to whether they were injected with a central nervous system stimulant or 0.9% w/v NaCl solution (saline). Correct responses were reinforced with water. 2. Different groups of rats learned to discriminate amphetamine or cocaine from saline. Dose-response curves and ED50 values were then determined in brief test sessions when no responses were reinforced. 3. In a crossover study, cocaine was tested in the rats trained to discriminate amphetamine from saline, and vice versa. The two drugs were largely interchangeable, but the ED50 values were increased, indicating a possible, subtle difference in their discriminative stimulus properties. 4. The results indicate the importance of complete crossover designs in combination with dose response determinations when attempting to classify drugs according to their discriminable properties.
摘要
- 对缺水的大鼠进行训练，使其在测试箱中根据注射的是中枢神经系统兴奋剂还是0.9% w/v氯化钠溶液（生理盐水）来按压左侧或右侧杠杆。正确反应会得到水的强化。2. 不同组的大鼠学会了区分苯丙胺或可卡因与生理盐水。然后在不强化反应的简短测试环节中确定剂量反应曲线和半数有效剂量（ED50）值。3. 在一项交叉研究中，对训练有素能区分苯丙胺与生理盐水的大鼠进行可卡因测试，反之亦然。这两种药物在很大程度上是可互换的，但ED50值增加，表明它们的辨别性刺激特性可能存在细微差异。4. 结果表明，在试图根据药物的可辨别特性对药物进行分类时，完全交叉设计与剂量反应测定相结合的重要性。
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