肾上腺素能神经末梢摄取对动脉血管对局部应用去甲肾上腺素敏感性的影响。
The effect of uptake by adrenergic nerve terminals on the sensitivity of arterial vessels to topically applied noradrenaline.
作者信息
Marshall J M
出版信息
Br J Pharmacol. 1977 Nov;61(3):429-32. doi: 10.1111/j.1476-5381.1977.tb08436.x.
Abstract
- Direct observations were made of the rat mesenteric vasculature in vivo. They showed a gradual increase in the sensitivity to topically applied noradrenaline from the larger arteries to the precapillary arterioles which was paralleled by a gradual decrease in the density of the adrenergic innervation. 2. Both cocaine and chronic denervation increased the sensitivity to noradrenaline of the innervated arterial vessels, approximately in proportion to the density to their innervation. They did not affect the sensitivity of the non-innervated precapillary arterioles. 3. It is concluded that the sensitivity gradient to topically applied noradrenaline results mainly from the uptake of the applied catecholamine by the perivascular nerve terminals.
摘要
- 对大鼠肠系膜血管系统进行了体内直接观察。观察结果显示，从较大动脉到毛细血管前微动脉，对局部应用去甲肾上腺素的敏感性逐渐增加，同时肾上腺素能神经支配密度逐渐降低。2. 可卡因和慢性去神经支配均增加了受神经支配的动脉血管对去甲肾上腺素的敏感性，其增加程度大致与神经支配密度成正比。它们并未影响未受神经支配的毛细血管前微动脉的敏感性。3. 得出的结论是，对局部应用去甲肾上腺素的敏感性梯度主要是由于血管周围神经末梢摄取了应用的儿茶酚胺所致。
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